Unpicking the metabolic contribution to cancer
Prostate cancer is a high-incidence male cancer that progresses to lethal incurable disease in a subset of diagnosed cases. Currently lethal disease is only robustly identified once the cancer has spread from the primary site, the prostate gland. This proposal aims to identify the cell communities/ecosystems in the prostate gland that nurture the evolution of lethal disease and decipher the biological processes that sustain them. We know that changes in how cancer cells use nutrients are important early-events in prostate cancer progression and are accompanied by changes in their genomes. Using new high-resolution spatial methods we will be able to find the small populations of cells in which these changes co-emerge. We will then isolate these cells and alter them/treat them before implanting them back into tissue to provide evidence that particular changes sustain their ability to colonise the prostate gland and acquire the potential to spread from the prostate and can be drugged.
3/6 complete
Imported from OpenAIRE | Grant NNF23OC0078934.
Open sourceOverview
Grant agreement NNF23OC0078934
Open sourceProstate cancer is a high-incidence male cancer that progresses to lethal incurable disease in a subset of diagnosed cases. Currently lethal disease is only robustly identified once the cancer has spread from the primary site, the prostate gland. This proposal aims to identify the cell communities/ecosystems in the prostate gland that nurture the evolution of lethal disease and decipher the biological processes that sustain them. We know that changes in how cancer cells use nutrients are important early-events in prostate cancer progression and are accompanied by changes in their genomes. Using new high-resolution spatial methods we will be able to find the small populations of cells in which these changes co-emerge. We will then isolate these cells and alter them/treat them before implanting them back into tissue to provide evidence that particular changes sustain their ability to colonise the prostate gland and acquire the potential to spread from the prostate and can be drugged.