State-of-the-art cell pulsatile physiological stretch & live cell imaging system
Studying cells in an environment that resembles normal physiology experienced in the body is desirable. In the University of Bristol we have multiple research groups who are interested in kidney, cardiovascular, tissue engineering and cancer cell/organoid biology. We have identified that growing cells in a system that allows dynamic pulsatile stretch that would mimic cardiac output (amplitude and frequency) would be highly beneficial for these groups. We would like to purchase a state-of-the-art stretch system that can simultaneously stretch multiple cell/organoid/tissue samples in an incubator for days to weeks (matching the situation in the body). Furthermore, it has the capability to video the specimens through an incubator located microscope and assess how proteins change in their cellular location through florescent tags. This equipment will be made available to all researchers in the University by being linked to our dedicated Wolfson Imaging Centre. Importantly, there is currently no other equipment that can do this in our University, so this equipment would facilitate an unmet need.
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Imported from UKRI Gateway to Research | Grant 1AF69B72-8E0A-45B4-90D9-0024CAB555DE.
Open sourceOverview
Grant agreement 1AF69B72-8E0A-45B4-90D9-0024CAB555DE
Open sourceStudying cells in an environment that resembles normal physiology experienced in the body is desirable. In the University of Bristol we have multiple research groups who are interested in kidney, cardiovascular, tissue engineering and cancer cell/organoid biology. We have identified that growing cells in a system that allows dynamic pulsatile stretch that would mimic cardiac output (amplitude and frequency) would be highly beneficial for these groups. We would like to purchase a state-of-the-art stretch system that can simultaneously stretch multiple cell/organoid/tissue samples in an incubator for days to weeks (matching the situation in the body). Furthermore, it has the capability to video the specimens through an incubator located microscope and assess how proteins change in their cellular location through florescent tags. This equipment will be made available to all researchers in the University by being linked to our dedicated Wolfson Imaging Centre. Importantly, there is currently no other equipment that can do this in our University, so this equipment would facilitate an unmet need.